Preheat oven to 350F.
Unfold the sheet of pastry dough and smooth it out with a rolling pin.
Place the pepperoni in a single layer on top of the sheet, leaving 1 1/2" border along the long edges.; press slightly to adhere.
Top with cheese and italian seasoning, again leaving a 1/2" border along the long sides. Brush the border with beaten egg.
Starting with the long side, roll up. Press along the edge to seal. Place in freezer for 10 minutes (optional, to aid in cutting).
Spray a cookie sheet with nonstick spray. Slice the pinwheel log into 1/2" slices, and place 1" apart on a cookie sheet.
Bake for 20-22 minutes, until pinwheels are puffed and golden. Serve warm.